Introduction: Stavropol region covers an area of 66300 m2. The relief of the region is diverse and is divided by absolute heights into low (less than 200 meters) and mountain (more than 500 meters). In this area, quite diverse zones are spread from the northern and northeastern semi-desert and steppe areas to the southern mountain-forest with alpine meadows and sterol glaciers. The marked variety of conditions for existence determines the diversity of the animal world of the Stavropol region, in particular, small mammals (MM). This analysis the confinement of small mammals to natural and anthropogenic biotopes to assess the impact of human activity on members of this group of animals. Materials and research methods: The material for this work was the collections of the autos during expeditions of stationary observations in various landscape zones of the Stavropol Territory in 2011-2018. Rodents were captured annually by various triads in the winter before the start of breeding, in early summer and in autumn in the end of breeding according to standard. During the reporting period 26700 traps-days wave worked out, as result of which 4086 small mammals were caught. Altogether, 10 species were observed in the study area in most of the territories. The Lessen Forest Mouse prevailed in the population structure of the MM, semi-desert landscapes of the Pre Caucasia-the house mouse. The greatest number of MM in the conditions of the Stavropol territory in all landscapes were noted in the end of summer the beginning of autumn, the minimum-ache end of winter early spring. Species composition is represented by the following species. The results of the study and their discussion: MM was monitored in various landscapes-climatic zones of the Stavropol Territory. In the forest-steppe landscapes zone, trap-days wave spent on captures individuals of rodents. In the province of forest-steppe landscapes of the region were spent 8100 trap-days, 1580 individuals were caught. The species composition is represented by 10 species of which the dominate species were: Small Forest Mouse (EID-40,1%), House Mouse (EID-27,5%). In the province of steppe landscapes in 2011-2018. Spent 14000 trap-days captured 1882 individuals MM. Species composition is represented by 9 species: forest small mouse (EID-44,4%) is dominate species. In the province of semi-desert landscapes of the region for study period spent 1300 trap-days, as a result caught 95 individuals MM. Species composition is represented by 4 species: House Mouse (EID-45,3%) is dominate species. In the province foothill, steppe and forest-steppe spent 3300trap-days, caught 529 individuals MM. Species composition is represented by 8 species: Little Wood Mouse (EID-73,1%) is dominate species.