APPLICATION OF ATOMIC-POWER MICROSCOPY AT RESEARCH OF BIOPHYSICAL PROPERTIES OF RED BLOOD CELLS MEMBRANES

Abstract

Research of morphological parameters of biological structures is an important task in diagnostics, as sizes and form of some structures determine their physiological properties. According to researchers, the erythrocyte possesses a community of metabolic processes, is easily allocated and now is recognized available model of living cell of an organism. An Atomic-power microscopy (АРМ) is one of methods of complex research of surfaces of different objects in micro- and nanometer range of sizes. Adjusting of metabolism of cage and its adaptation reorganization in response to various influences are substantially connected with the physical and chemical processes happening in its membrane. The use of AFM provides the possibility of direct observation of those molecular structural changes, which had previously indicated only indirect data. Except receiving with high resolution of quantitative data on geometry of objects of AFM allows to receive also topographical images of such physical parameters of membranes as hardness, adhesive ability and molecular friction.