Application of Scanning Probe Microscopy in the study of spontaneous aggregation of thrombocytes in patients with mutations in the platelet receptor glycoprotein IIb / IIIa
Abstract
The paper presents the results of the use of scanning probe microscopy to analyze platelet aggregates in women with normal pregnancy and in the presence of polymor-phisms in the gene for platelet glycoprotein IIb / IIIa. It was found that the size of the aggregates healthy pregnant women is higher in healthy non-pregnant women, but do not reach the perfor-mance of women with thrombophilia. It is noted that a defect in the gene for glycoprotein IIb / IIIa platelet functional activity increases.
About the Authors
Anna Muratova
NCFU
Russian Federation
Russian Federation
Tatiana Petrovna Bondar
NCFU
Russian Federation
Russian Federation
Evgeny Melchenko
NCFU
Russian Federation
Russian Federation
References
1. Бондарь Т. П., Мельченко Е. А Использование сканирующей зондовой микроскопии для оценки состояния периферического звена эритрона у детей // Вестник Северо-Кавказского федерального университета. 2013. №1 (34). С. 113-115.
2. Мацакария А. Д., Бицадзе В. О. и др. Тромбофилитические состояния в акушерской практике. М.: Медицина, 2001. 703 с.
3. Муратова А. Ю., Бондарь Т. П., Сафонова Л. Г. Показатели тромбоцитарного звена гемостаза в диагностике тромбофилий у беременных // Клинич. лабораторная диагностика. 2008. № 9. С. 10-11.
Review
For citations:
Muratova A., Bondar T.P., Melchenko E. Application of Scanning Probe Microscopy in the study of spontaneous aggregation of thrombocytes in patients with mutations in the platelet receptor glycoprotein IIb / IIIa. Science. Innovations. Technologies. 2014;(4):199-207. (In Russ.)
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